Across TCGA pan-cancer cohorts, VKORC1L1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of VKORC1L1’s most consistent transcriptional readouts.
The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where VKORC1L1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types VKORC1L1 is over-expressed in tumor.
PDAC, COAD, and HNSC are the cancer types where VKORC1L1 tumor–normal differential expression is most reproducible.
mass-spec protein tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VKORC1L1 mass-spec protein (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.