Across TCGA patient cohorts, VKORC1L1 protein abundance is significantly associated with the RNA expression of many other genes, with 9,905 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible VKORC1L1-associated genes across cancer lineages are TMEM248, TRIM24, and CRCP. Each is linked with VKORC1L1 in more than 4 cancer types. Because this analysis shows association rather than direction, both VKORC1L1-to-partner and partner-to-VKORC1L1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VKORC1L1→partner) and Y-score (partner→VKORC1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TMEM248 →	+0.641	+0.480	<.001	<.001	3	5
HNSC	TRIM24 →	+0.876	+0.385	<.001	.001	3	5
HNSC	CRCP →	+0.799	+0.635	<.001	<.001	3	5
UCEC	AVL9 →	+0.443	+0.519	<.001	<.001	3	5
OV	PPP1R26-AS1 →	+0.983	+1.365	.001	.003	3	4
LSCC	MEFV →	-0.789	-0.331	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,905 associations by consensus.

Exploration

VKORC1L1 survival (RNA) · tumor vs normal (RNA) · all VKORC1L1 data types