Across TCGA patient cohorts, VKORC1L1 mutation is significantly associated with the RNA expression of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VKORC1L1-associated genes across cancer lineages are RNU6-936P, RN7SKP265, and OR9L1P. Each is linked with VKORC1L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VKORC1L1-to-partner and partner-to-VKORC1L1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VKORC1L1→partner) and Y-score (partner→VKORC1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-936P →	+0.410	+5.411	<.001	.005	3	2
UCEC	RN7SKP265 →	+0.191	+4.242	<.001	.006	3	2
BLCA	OR9L1P →	+0.060	+5.685	<.001	.003	3	1
BLCA	LINC02297 →	+0.076	+5.251	<.001	.006	3	1
UCEC	RBAK-RBAKDN →	+0.122	+2.990	<.001	.006	3	1
UCEC	TRAJ37 →	+0.633	+2.818	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Exploration

VKORC1L1 survival (RNA) · tumor vs normal (RNA) · all VKORC1L1 data types