VKORC1

Across TCGA pan-cancer cohorts, VKORC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated VKORC1 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher VKORC1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated VKORC1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where VKORC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.874	0.673	.002	35	view →
PDAC	DFS	Tertile	All	0.731	0.892	.007	27	view →
CCRCC	DFS	Quartile	II,III,IV	0.492	0.860	.006	23	view →
LUAD	OS	Median	III,IV	0.817	0.335	.004	6	view →
GBM	OS	Quartile	All	0.282	0.624	.002	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

VKORC1–HNSC (DFS)

Open the HNSC breakdown →