VKORC1

Across TCGA patient cohorts, VKORC1 mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VKORC1-associated genes across cancer lineages are Basophils and Epithelial cells. Each is linked with VKORC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VKORC1-to-partner and partner-to-VKORC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Basophils grouped by VKORC1-low versus VKORC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VKORC1→partner) and Y-score (partner→VKORC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Basophils →	+0.212	+3.169	.023	.020	2	1
UCEC	Epithelial cells →	-0.157	-3.169	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Basophils by VKORC1 expression — UCEC

Explore this box plot interactively →