VKORC1

Across TCGA cell cohorts, VKORC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,087 significant associations in total. CNS shows the largest number of these associations.

The most reproducible VKORC1-associated GO terms across cancer lineages are Calcium-independent cell-matrix adhesion, Peptidyl-lysine oxidation, and Collagen biosynthetic process. Each is linked with VKORC1 in more than 14 cancer types. Because this analysis shows association rather than direction, both VKORC1-to-partner and partner-to-VKORC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Calcium-independent cell-matrix adhesion grouped by VKORC1-low versus VKORC1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VKORC1→partner) and Y-score (partner→VKORC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Calcium-independent cell-matrix adhesion →	+0.233	+1.028	<.001	<.001	2	15
BONE	Peptidyl-lysine oxidation →	+1.314	+1.130	.002	<.001	3	12
CNS	Collagen biosynthetic process →	+0.260	+0.845	<.001	<.001	3	12
BLOOD_Leukemia	Keratinocyte development →	+0.737	+0.574	<.001	<.001	3	12
OVARY	ADP catabolic process →	+0.151	+1.329	<.001	<.001	3	12
URINARY_TRACT	IMP salvage →	+0.205	+1.004	.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,087 associations by consensus.

Calcium-independent cell-matrix adhesion by VKORC1 expression — BONE

Explore this box plot interactively →