VIPR2

Across TCGA cell cohorts, VIPR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,255 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible VIPR2-associated GO terms across cancer lineages are Positive regulation of DNA repair, Regulation of DNA-templated transcription elongation, and Estrous cycle. Each is linked with VIPR2 in more than 5 cancer types. Because this analysis shows association rather than direction, both VIPR2-to-partner and partner-to-VIPR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA repair grouped by VIPR2-low versus VIPR2-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VIPR2→partner) and Y-score (partner→VIPR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of DNA repair →	+0.082	+1.266	<.001	.003	3	6
OVARY	Regulation of DNA-templated transcription elongation →	+0.040	+0.273	.001	.005	3	5
OVARY	Estrous cycle →	+0.137	+0.387	.002	.007	3	5
OVARY	Regulation of translational initiation →	+0.074	+0.370	<.001	.009	3	5
LUNG_NSCLC_LUSC	Sterol transport →	+0.097	+0.084	.003	.006	3	5
PANCREAS	Negative regulation of Notch signaling pathway →	+0.050	+0.029	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,255 associations by consensus.

Positive regulation of DNA repair by VIPR2 expression — SOFT_TISSUE

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