VIPR2

Across TCGA cell cohorts, VIPR2 mutation is significantly associated with the drug of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VIPR2-associated genes across cancer lineages are Niraparib, GSK2801, and Olaparib. Each is linked with VIPR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VIPR2-to-partner and partner-to-VIPR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Niraparib grouped by VIPR2-low versus VIPR2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VIPR2→partner) and Y-score (partner→VIPR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Niraparib →	+0.435	+2.646	.013	.047	3	1
LARGE_INTESTINE	GSK2801 →	+0.323	+2.649	.043	.046	3	1
LARGE_INTESTINE	Olaparib →	+0.409	+2.646	.028	.047	2	1
LARGE_INTESTINE	GSK626616AC →	+0.345	+2.777	.030	.038	2	1
LARGE_INTESTINE	Venotoclax →	+0.159	+2.722	.046	.040	2	1
LARGE_INTESTINE	CDK9_5038 →	+0.582	+2.906	.035	.033	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Niraparib by VIPR2 expression — LARGE_INTESTINE

Explore this box plot interactively →