VIPR1

Across TCGA patient cohorts, VIPR1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VIPR1-associated genes across cancer lineages are IGFBP2, mTOR_pS2448, and P-Cadherin. Each is linked with VIPR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VIPR1-to-partner and partner-to-VIPR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by VIPR1-low versus VIPR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VIPR1→partner) and Y-score (partner→VIPR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.652	-2.222	.018	.011	3	1
UCEC	mTOR_pS2448 →	-0.159	-2.439	.011	.019	3	1
UCEC	P-Cadherin →	-0.131	-3.169	.032	.018	3	1
UCEC	Shc_pY317 →	-0.159	-2.115	.013	.017	3	1
UCEC	Tuberin →	+0.252	+2.179	.027	.034	3	1
UCEC	VHL →	-0.580	-2.000	.044	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

IGFBP2 by VIPR1 expression — UCEC

Explore this box plot interactively →