VIPR1

Across TCGA cell cohorts, VIPR1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VIPR1-associated genes across cancer lineages are MS4A4A, DEFA4, and TBC1D21. Each is linked with VIPR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VIPR1-to-partner and partner-to-VIPR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A4A grouped by VIPR1-low versus VIPR1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VIPR1→partner) and Y-score (partner→VIPR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MS4A4A →	+0.136	+3.000	<.001	.006	3	1
LARGE_INTESTINE	DEFA4 →	+0.022	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	ACSM6 →	+0.020	+3.921	<.001	.001	3	1
LARGE_INTESTINE	ARGFX →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	PFN3 →	+0.103	+3.297	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MS4A4A by VIPR1 expression — LARGE_INTESTINE

Explore this box plot interactively →