VIPAS39

Across TCGA cell cohorts, VIPAS39 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VIPAS39-associated genes across cancer lineages are OR6P1, SCGB1C1, and ADGRA1. Each is linked with VIPAS39 in more than 1 cancer types. Because this analysis shows association rather than direction, both VIPAS39-to-partner and partner-to-VIPAS39 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6P1 grouped by VIPAS39-low versus VIPAS39-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VIPAS39→partner) and Y-score (partner→VIPAS39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR6P1 →	+0.016	+5.201	<.001	.006	3	1
BLOOD_Leukemia	SCGB1C1 →	+0.129	+5.539	<.001	.003	3	1
BLOOD_Leukemia	ADGRA1 →	+0.006	+5.201	<.001	.006	3	1
SKIN	OR1L1 →	+0.017	+5.022	<.001	.002	3	1
LUNG_NSCLC_LUAD	PSKH2 →	+0.021	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	GPHB5 →	+0.043	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OR6P1 by VIPAS39 expression — BLOOD_Leukemia

Explore this box plot interactively →