Across TCGA pan-cancer cohorts, VIM2P RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of VIM2P’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where VIM2P RNA is repressed in tumor relative to normal tissue. In most cancer types VIM2P is over-expressed in tumor, although a few such as BRCA and COAD show the opposite, repressed pattern.
BRCA, COAD, and READ are the cancer types where VIM2P tumor–normal differential expression is most reproducible.