VIM

Across TCGA pan-cancer cohorts, VIM mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated VIM data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher VIM mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated VIM expression acts as an unfavorable survival marker.

CCRCC, LSCC, and PDAC are the cancer types where VIM mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	II,III,IV	0.673	0.930	.012	16	view →
LSCC	OS	Median	All	0.920	1.000	.008	9	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	3	view →
LUAD	DFS	Quartile	III,IV	0.464	0.993	.040	3	view →
GBM	OS	Tertile	All	0.770	0.904	.010	2	view →
HNSC	DFS	Tertile	II,III,IV	0.490	0.737	.020	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

VIM–CCRCC (OS)

Open the CCRCC breakdown →