VILL

Across TCGA patient cohorts, VILL mutation is significantly associated with the RNA expression of many other genes, with 2,053 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VILL-associated genes across cancer lineages are RNU1-62P, ITPK1, and JOSD1. Each is linked with VILL in more than 3 cancer types. Because this analysis shows association rather than direction, both VILL-to-partner and partner-to-VILL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-62P grouped by VILL-low versus VILL-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VILL→partner) and Y-score (partner→VILL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU1-62P →	+0.174	+4.539	<.001	.008	3	4
SKCM	ITPK1 →	+0.803	+3.465	.001	.003	3	3
UCEC	JOSD1 →	+0.380	+3.700	.006	.001	3	3
HNSC	RNU6-956P →	+0.366	+7.954	<.001	.008	3	3
UCEC	NR2C2AP →	+0.368	+2.008	.005	.005	3	3
UCEC	RRAGC →	+0.354	+2.513	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,053 associations by consensus.

RNU1-62P by VILL expression — CESC

Explore this box plot interactively →