VILL

Across TCGA patient cohorts, VILL mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VILL-associated genes across cancer lineages are Caspase-7-cleavedD198, JNK_pT183_Y185, and Akt_pT308. Each is linked with VILL in more than 2 cancer types. Because this analysis shows association rather than direction, both VILL-to-partner and partner-to-VILL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by VILL-low versus VILL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VILL→partner) and Y-score (partner→VILL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.511	+2.479	.028	.010	3	3
UCEC	JNK_pT183_Y185 →	-0.171	-2.000	.009	.030	3	2
UCEC	Akt_pT308 →	+0.526	+2.459	.033	.018	3	2
UCEC	14-3-3_beta →	-0.130	-3.673	<.001	.001	3	1
UCEC	EGFR_pY1068 →	-0.209	-2.000	.034	.010	3	1
UCEC	A-Raf_pS299 →	-0.130	-3.321	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Caspase-7-cleavedD198 by VILL expression — UCEC

Explore this box plot interactively →