VILL

Across TCGA cell cohorts, VILL RNA expression is significantly associated with the go_rna of many other GO terms, with 4,423 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible VILL-associated GO terms across cancer lineages are Cytotoxic T cell degranulation, Regulation of ruffle assembly, and Positive regulation of protein localization to plasma membrane. Each is linked with VILL in more than 11 cancer types. Because this analysis shows association rather than direction, both VILL-to-partner and partner-to-VILL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytotoxic T cell degranulation grouped by VILL-low versus VILL-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VILL→partner) and Y-score (partner→VILL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Cytotoxic T cell degranulation →	+0.313	+1.192	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Regulation of ruffle assembly →	+0.146	+1.834	<.001	<.001	3	10
STOMACH	Positive regulation of protein localization to plasma membrane →	+0.127	+3.034	<.001	<.001	3	10
STOMACH	Sensory perception of salty taste →	+1.426	+3.011	<.001	<.001	3	10
STOMACH	ERBB3 signaling pathway →	+0.189	+2.885	<.001	<.001	3	9
STOMACH	ERBB2-ERBB3 signaling pathway →	+0.189	+2.885	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,423 associations by consensus.

Cytotoxic T cell degranulation by VILL expression — BONE

Explore this box plot interactively →