VILL

Across TCGA cell cohorts, VILL mutation is significantly associated with the mutation status of many other genes, with 3,735 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VILL-associated genes across cancer lineages are TENM1, FGR, and HECW2. Each is linked with VILL in more than 4 cancer types. Because this analysis shows association rather than direction, both VILL-to-partner and partner-to-VILL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TENM1 grouped by VILL-low versus VILL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VILL→partner) and Y-score (partner→VILL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TENM1 →	+1.900	+4.091	<.001	<.001	1	5
SKIN	FGR →	+4.638	+4.638	<.001	<.001	1	4
STOMACH	HECW2 →	+4.807	+4.807	.008	.008	1	4
STOMACH	OXR1 →	+4.807	+4.807	.008	.008	1	4
SKIN	SHROOM3 →	+3.053	+3.718	.006	.006	1	4
SKIN	INPPL1 →	+3.053	+3.718	.006	.006	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,735 associations by consensus.

TENM1 by VILL expression — LARGE_INTESTINE

Explore this box plot interactively →