Across TCGA pan-cancer cohorts, VHLL Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated VHLL data layer compared with 16 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher VHLL Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated VHLL expression acts as an unfavorable survival marker.

THYM and LUSC are the cancer types where VHLL Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
LUSC	DFS	Median	All	0.064	0.791	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: VHLL tumor-vs-normal RNA expression · all VHLL data types