Across TCGA patient cohorts, VHLL mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VHLL-associated genes across cancer lineages are Lck, MSH2, and p38-MAPK. Each is linked with VHLL in more than 1 cancer types. Because this analysis shows association rather than direction, both VHLL-to-partner and partner-to-VHLL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VHLL→partner) and Y-score (partner→VHLL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.445	+3.169	<.001	.020	3	1
UCEC	MSH2 →	-0.502	-3.169	<.001	.020	3	1
UCEC	p38-MAPK →	+0.189	+2.827	.035	.035	3	1
UCEC	Syk →	+0.532	+3.183	.009	.010	3	1
UCEC	Caspase-7-cleavedD198 →	+1.261	+3.189	<.001	.010	3	1
UCEC	MSH6 →	-0.784	-3.159	<.001	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

VHLL survival (RNA) · tumor vs normal (RNA) · all VHLL data types