Across TCGA patient cohorts, VGLL3 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VGLL3-associated genes across cancer lineages are A-Raf_pS299, FoxM1, and MEK1. Each is linked with VGLL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both VGLL3-to-partner and partner-to-VGLL3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VGLL3→partner) and Y-score (partner→VGLL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.115	-2.459	.005	.018	3	2
UCEC	FoxM1 →	+0.178	+2.070	.047	.001	3	2
UCEC	MEK1 →	+0.493	+4.087	<.001	<.001	2	3
UCEC	Notch1 →	+0.179	+2.817	<.001	.001	3	2
UCEC	Caspase-8 →	-0.183	-2.295	.035	.005	3	2
LUAD	p38-MAPK →	-0.227	-2.917	.004	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

VGLL3 survival (RNA) · tumor vs normal (RNA) · all VGLL3 data types