VGLL1

Across TCGA patient cohorts, VGLL1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VGLL1-associated genes across cancer lineages are STAT3_pY705, Caspase-8, and IGFBP2. Each is linked with VGLL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VGLL1-to-partner and partner-to-VGLL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by VGLL1-low versus VGLL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VGLL1→partner) and Y-score (partner→VGLL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.429	-3.321	<.001	.009	3	2
UCEC	Caspase-8 →	-0.228	-2.432	.033	.018	3	2
UCEC	IGFBP2 →	-0.694	-1.700	.011	.044	3	1
UCEC	JNK2 →	+0.250	+2.222	.003	.011	3	1
UCEC	Ku80 →	+0.257	+1.713	.010	.027	3	1
UCEC	Notch1 →	+0.205	+3.472	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

STAT3_pY705 by VGLL1 expression — UCEC

Explore this box plot interactively →