VGF

Across TCGA pan-cancer cohorts, VGF Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated VGF data layer compared with 27 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in sarcoma (SARC), where higher VGF Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated VGF expression acts as an unfavorable survival marker.

SARC, LIHC, and LUSC are the cancer types where VGF Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SARC	OS	Median	All	0.183	0.839	<.001	12	view →
LIHC	OS	Median	All	0.015	0.784	<.001	12	view →
LUSC	OS	Median	All	0.138	0.818	.003	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

VGF–SARC (OS)

Open the SARC breakdown →