VGF

Across TCGA pan-cancer cohorts, VGF mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated VGF data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher VGF mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated VGF expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

LUAD, PDAC, and CCRCC are the cancer types where VGF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.241	0.837	.001	25	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	24	view →
CCRCC	DFS	Median	II,III,IV	0.376	1.000	.038	4	view →
GBM	OS	Median	All	0.301	0.436	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

VGF–LUAD (OS)

Open the LUAD breakdown →