VGF

Across TCGA patient cohorts, VGF mutation is significantly associated with the RNA expression of many other genes, with 153 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible VGF-associated genes across cancer lineages are DNAJB5P1, RPL32P19, and LYPLA1P1. Each is linked with VGF in more than 1 cancer types. Because this analysis shows association rather than direction, both VGF-to-partner and partner-to-VGF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAJB5P1 grouped by VGF-low versus VGF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VGF→partner) and Y-score (partner→VGF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DNAJB5P1 →	+0.303	+3.332	<.001	.004	3	2
COAD	RPL32P19 →	+0.342	+5.602	<.001	<.001	3	2
UCEC	LYPLA1P1 →	+0.111	+4.727	<.001	.003	3	2
LUSC	RNU1-146P →	+0.516	+3.447	<.001	.003	3	2
LUSC	NEFHP1 →	+0.085	+3.171	<.001	.006	3	2
LUSC	IFNNP1 →	+0.055	+4.584	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 153 associations by consensus.

DNAJB5P1 by VGF expression — UCEC

Explore this box plot interactively →