VGF

Across TCGA cell cohorts, VGF RNA expression is significantly associated with the go_rna of many other GO terms, with 1,996 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible VGF-associated GO terms across cancer lineages are Negative regulation of Rac protein signal transduction, Primary alcohol biosynthetic process, and Regulation of gamma-aminobutyric acid secretion. Each is linked with VGF in more than 6 cancer types. Because this analysis shows association rather than direction, both VGF-to-partner and partner-to-VGF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of Rac protein signal transduction grouped by VGF-low versus VGF-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VGF→partner) and Y-score (partner→VGF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Negative regulation of Rac protein signal transduction →	+1.087	+2.674	<.001	<.001	3	7
LUNG_SCLC	Primary alcohol biosynthetic process →	-0.304	-2.310	<.001	.003	3	6
UPPER_AERODIGESTIVE_TRACT	Regulation of gamma-aminobutyric acid secretion →	+0.843	+0.492	.001	.007	3	6
PANCREAS	Neuron maturation →	-0.101	-1.547	.001	.007	3	6
KIDNEY	Response to staurosporine →	-0.162	-0.802	<.001	.005	2	7
KIDNEY	Cellular response to staurosporine →	-0.162	-0.802	<.001	.005	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,996 associations by consensus.

Negative regulation of Rac protein signal transduction by VGF expression — LARGE_INTESTINE

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