VEZF1

Across TCGA patient cohorts, VEZF1 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VEZF1-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, p38-MAPK_pT180_Y182, and Smad3. Each is linked with VEZF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VEZF1-to-partner and partner-to-VEZF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by VEZF1-low versus VEZF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VEZF1→partner) and Y-score (partner→VEZF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.428	+2.710	.025	.003	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.557	-2.222	<.001	.010	3	2
UCEC	Smad3 →	+0.132	+2.000	.019	.009	3	2
UCEC	ATM →	-0.551	-3.308	.001	.009	3	2
UCEC	eEF2 →	+0.437	+2.584	.001	.010	3	1
UCEC	EGFR_pY1068 →	-0.344	-2.662	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

Acetyl-a-Tubulin-Lys40 by VEZF1 expression — UCEC

Explore this box plot interactively →