Across TCGA patient cohorts, VEPH1 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VEPH1-associated genes across cancer lineages are C-Raf, 14-3-3_beta, and eEF2. Each is linked with VEPH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VEPH1-to-partner and partner-to-VEPH1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VEPH1→partner) and Y-score (partner→VEPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C-Raf →	+0.222	+2.841	.003	.033	3	2
UCEC	14-3-3_beta →	-0.081	-1.673	.020	.040	3	2
UCEC	eEF2 →	+0.286	+2.321	.021	.033	3	2
UCEC	FoxM1 →	+0.230	+2.938	.010	<.001	3	2
UCEC	JNK_pT183_Y185 →	-0.180	-1.906	.002	.015	3	2
UCEC	Notch1 →	+0.194	+2.916	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Exploration

VEPH1 survival (RNA) · tumor vs normal (RNA) · all VEPH1 data types