VEGFA

Across TCGA pan-cancer cohorts, VEGFA mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated VEGFA data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher VEGFA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated VEGFA expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

PDAC, LUAD, and CCRCC are the cancer types where VEGFA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.593	0.927	.003	53	view →
LUAD	DFS	Tertile	All	0.438	0.798	.003	24	view →
CCRCC	DFS	Quartile	All	0.614	0.936	<.001	20	view →
HNSC	DFS	Quartile	II,III,IV	0.910	0.267	.022	17	view →
LSCC	DFS	Median	All	0.903	0.689	.006	11	view →
GBM	OS	Quartile	All	0.306	0.570	.023	7	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

VEGFA–PDAC (DFS)

Open the PDAC breakdown →