VDR

Across TCGA pan-cancer cohorts, VDR mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated VDR data layer compared with 24 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher VDR mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated VDR expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

PDAC, CCRCC, and LSCC are the cancer types where VDR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.297	0.484	.011	22	view →
CCRCC	DFS	Median	All	1.000	0.600	.008	8	view →
LSCC	DFS	Quartile	II,III,IV	0.486	0.806	.020	3	view →
GBM	OS	Median	All	0.300	0.690	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

VDR–PDAC (DFS)

Open the PDAC breakdown →