VDAC2P4

Across TCGA pan-cancer cohorts, VDAC2P4 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated VDAC2P4 data layer.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher VDAC2P4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated VDAC2P4 expression acts as an unfavorable survival marker, although some lineages such as BRCA and PAAD show a favorable association.

OV, THCA, and KIRP are the cancer types where VDAC2P4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Tertile	All	0.421	0.565	<.001	102	view →
THCA	DFS	Tertile	All	0.550	0.877	.003	90	view →
KIRP	OS	Tertile	II,III,IV	0.111	0.769	<.001	75	view →
BRCA	DFS	Tertile	All	0.970	0.891	<.001	60	view →
UCEC	DFS	Tertile	All	0.823	0.902	.013	60	view →
COAD	DFS	Tertile	IV	0.035	0.501	<.001	42	view →
ESCA	OS	Tertile	IV	0.143	0.650	.004	36	view →
KIRC	DFS	Tertile	IV	0.335	0.676	<.001	36	view →
LIHC	OS	Tertile	III,IV	0.118	0.615	.003	36	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	27	view →
MESO	DFS	Tertile	III,IV	0.200	0.439	.009	27	view →
CESC	DFS	Tertile	III,IV	0.273	0.640	.046	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

VDAC2P4–OV (DFS)

Open the OV breakdown →