Across TCGA pan-cancer cohorts, VDAC2P3 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated VDAC2P3 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher VDAC2P3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated VDAC2P3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, UVM, and SKCM are the cancer types where VDAC2P3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.767	0.617	<.001	126	view →
UVM	DFS	Tertile	III,IV	0.072	0.709	<.001	123	view →
SKCM	OS	Median	All	0.400	0.277	<.001	119	view →
KIRP	DFS	Quartile	All	0.318	0.643	<.001	78	view →
CESC	DFS	Quartile	IV	0.852	0.301	.002	52	view →
UCS	DFS	Tertile	II,III,IV	0.660	0.332	.026	30	view →
LGG	OS	Tertile	All	0.334	0.543	.002	24	view →
UCEC	DFS	Tertile	IV	0.774	0.314	.015	24	view →
BRCA	DFS	Median	III,IV	0.588	0.377	.001	22	view →
TGCT	DFS	Tertile	All	0.949	0.713	.003	10	view →
ACC	DFS	Tertile	All	0.195	0.748	.003	9	view →
READ	DFS	Quartile	III,IV	0.678	0.204	.012	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

Exploration

Same gene, other analysis: VDAC2P3 tumor-vs-normal RNA expression · all VDAC2P3 data types