VDAC2

Across TCGA patient cohorts, VDAC2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VDAC2-associated genes across cancer lineages are EGFR_pY1068, Ku80, and Caspase-8. Each is linked with VDAC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VDAC2-to-partner and partner-to-VDAC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by VDAC2-low versus VDAC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VDAC2→partner) and Y-score (partner→VDAC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.339	-3.321	.010	.010	3	1
UCEC	Ku80 →	+0.261	+2.183	.034	.035	3	1
UCEC	Caspase-8 →	-0.303	-2.973	.021	.035	3	1
UCEC	MEK1 →	+0.410	+3.000	.032	.036	2	1
UCEC	c-Jun_pS73 →	-0.173	-2.990	.037	.036	2	1
UCEC	p62 Lck ligand →	+0.358	+3.321	.035	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

EGFR_pY1068 by VDAC2 expression — UCEC

Explore this box plot interactively →