VDAC2

Across TCGA cell cohorts, VDAC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,630 significant associations in total. CNS shows the largest number of these associations.

The most reproducible VDAC2-associated GO terms across cancer lineages are Positive regulation of mitochondrial ATP synthesis coupled electron transport, DAMP biosynthetic process, and Purine deoxyribonucleoside monophosphate biosynthetic process. Each is linked with VDAC2 in more than 13 cancer types. Because this analysis shows association rather than direction, both VDAC2-to-partner and partner-to-VDAC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mitochondrial ATP synthesis coupled electron transport grouped by VDAC2-low versus VDAC2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VDAC2→partner) and Y-score (partner→VDAC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mitochondrial ATP synthesis coupled electron transport →	+0.112	+0.848	<.001	<.001	3	14
BLOOD_Leukemia	DAMP biosynthetic process →	+0.112	+0.547	<.001	<.001	3	12
BLOOD_Leukemia	Purine deoxyribonucleoside monophosphate biosynthetic process →	+0.112	+0.547	<.001	<.001	3	12
LUNG_NSCLC_LUSC	DNA replication, removal of RNA primer →	+0.126	+0.692	.002	.002	3	12
CNS	Regulation of mitochondrial RNA catabolic process →	+0.111	+0.618	<.001	<.001	3	11
CNS	Positive regulation of mitochondrial RNA catabolic process →	+0.112	+0.651	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,630 associations by consensus.

Positive regulation of mitochondrial ATP synthesis coupled electron transport by VDAC2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →