Across TCGA pan-cancer cohorts, VDAC1P8 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated VDAC1P8 data layer.
The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher VDAC1P8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated VDAC1P8 expression acts as an unfavorable survival marker, although some lineages such as UCS and READ show a favorable association.
LIHC, MESO, and UCS are the cancer types where VDAC1P8 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.