VDAC1P1

Across TCGA patient cohorts, VDAC1P1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VDAC1P1-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and ER-alpha_pS118. Each is linked with VDAC1P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VDAC1P1-to-partner and partner-to-VDAC1P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by VDAC1P1-low versus VDAC1P1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VDAC1P1→partner) and Y-score (partner→VDAC1P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.146	-2.680	<.001	.006	3	1
UCEC	eIF4E →	+0.201	+2.415	.017	.003	3	1
UCEC	ER-alpha_pS118 →	+0.306	+3.013	.034	.018	3	1
UCEC	Fibronectin →	-0.309	-2.575	.019	.010	3	1
UCEC	ACC_pS79 →	+0.394	+1.906	.004	.016	3	1
UCEC	G6PD →	-0.262	-3.308	.044	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

14-3-3_beta by VDAC1P1 expression — UCEC

Explore this box plot interactively →