Across TCGA pan-cancer cohorts, VDAC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated VDAC1 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher VDAC1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated VDAC1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where VDAC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	III,IV	0.505	0.853	.001	34	view →
LUAD	DFS	Quartile	All	0.348	0.885	.002	18	view →
PDAC	OS	Tertile	II,III,IV	0.663	0.352	.002	15	view →
HNSC	DFS	Quartile	IV	0.849	0.498	.029	2	view →
LSCC	DFS	Quartile	II,III,IV	1.000	0.893	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: VDAC1 tumor-vs-normal RNA expression · all VDAC1 data types