Across TCGA patient cohorts, VDAC1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VDAC1-associated genes across cancer lineages are ACVRL1, JNK_pT183_Y185, and Ku80. Each is linked with VDAC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VDAC1-to-partner and partner-to-VDAC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VDAC1→partner) and Y-score (partner→VDAC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACVRL1 →	-0.141	-2.439	.018	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.177	-2.102	.016	.019	3	1
UCEC	Ku80 →	+0.223	+2.128	.031	.010	3	1
UCEC	MEK1 →	+0.373	+2.321	.019	.034	3	1
UCEC	p27_pT157 →	-0.068	-3.282	.006	.010	3	1
UCEC	Rab11 →	-0.132	-2.302	.037	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

VDAC1 survival (RNA) · tumor vs normal (RNA) · all VDAC1 data types