VCY

Across TCGA pan-cancer cohorts, VCY RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated VCY data layer compared with 1 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher VCY RNA is associated with worse overall survival. In most high-consensus cancer types, elevated VCY expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

COAD, KIRC, and LIHC are the cancer types where VCY RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	All	0.159	0.618	<.001	123	view →
KIRC	DFS	Tertile	III,IV	0.038	0.750	<.001	72	view →
LIHC	OS	Tertile	II,III,IV	0.395	0.719	.001	69	view →
UCEC	DFS	Tertile	All	0.184	0.838	<.001	54	view →
KIRP	DFS	Tertile	All	0.127	0.857	<.001	54	view →
SKCM	DFS	Tertile	III,IV	0.169	0.608	<.001	48	view →
SCLC	OS	Tertile	All	0.082	0.708	<.001	36	view →
THYM	OS	Tertile	All	0.352	0.884	<.001	24	view →
LUAD	OS	Tertile	All	0.016	0.835	<.001	18	view →
LUSC	OS	Tertile	All	0.189	0.724	.031	9	view →
BLCA	OS	Tertile	II,III,IV	1.000	0.427	.047	6	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

VCY–COAD (OS)

Open the COAD breakdown →