VCPKMT

Across TCGA cell cohorts, VCPKMT mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VCPKMT-associated genes across cancer lineages are TBC1D21, OR10W1, and CCER1. Each is linked with VCPKMT in more than 1 cancer types. Because this analysis shows association rather than direction, both VCPKMT-to-partner and partner-to-VCPKMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D21 grouped by VCPKMT-low versus VCPKMT-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VCPKMT→partner) and Y-score (partner→VCPKMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D21 →	+0.020	+6.022	<.001	.001	3	1
LARGE_INTESTINE	OR10W1 →	+0.022	+4.977	<.001	.007	3	1
LARGE_INTESTINE	CCER1 →	+0.012	+4.977	<.001	.007	3	1
LARGE_INTESTINE	PYDC2 →	+0.145	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TBC1D21 by VCPKMT expression — LARGE_INTESTINE

Explore this box plot interactively →