VCPKMT

Across TCGA cell cohorts, VCPKMT mutation is significantly associated with the mutation status of many other genes, with 645 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VCPKMT-associated genes across cancer lineages are NAA25, MFSD13A, and ZNF395. Each is linked with VCPKMT in more than 2 cancer types. Because this analysis shows association rather than direction, both VCPKMT-to-partner and partner-to-VCPKMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NAA25 grouped by VCPKMT-low versus VCPKMT-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VCPKMT→partner) and Y-score (partner→VCPKMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	NAA25 →	+5.392	+5.392	.004	.004	1	3
UPPER_AERODIGESTIVE_TRACT	MFSD13A →	+5.392	+5.392	.004	.004	1	3
UPPER_AERODIGESTIVE_TRACT	ZNF395 →	+5.392	+5.392	.004	.004	1	3
LARGE_INTESTINE	CITED2 →	+5.523	+5.523	.003	.003	1	3
UPPER_AERODIGESTIVE_TRACT	SEMA3A →	+5.392	+5.392	.004	.004	1	2
UPPER_AERODIGESTIVE_TRACT	NFE2L1 →	+5.392	+5.392	.004	.004	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 645 associations by consensus.

NAA25 by VCPKMT expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →