VCP

Across TCGA pan-cancer cohorts, VCP mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated VCP data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher VCP mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated VCP expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where VCP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.903	1.000	.006	15	view →
PDAC	DFS	Tertile	All	0.928	0.721	.010	6	view →
HNSC	DFS	Quartile	III,IV	0.949	0.631	.006	5	view →
GBM	OS	Median	All	0.513	0.285	.049	2	view →
LUAD	DFS	Quartile	II,III,IV	0.885	0.839	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

VCP–LSCC (DFS)

Open the LSCC breakdown →