VCL

Across TCGA pan-cancer cohorts, VCL Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated VCL data layer compared with 31 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher VCL Mutation is associated with better overall survival. In most high-consensus cancer types, elevated VCL expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, LIHC, and LUAD are the cancer types where VCL Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	0.906	0.449	.011	16	view →
LIHC	DFS	Median	All	0.050	0.556	<.001	15	view →
LUAD	OS	Median	All	0.246	0.700	<.001	6	view →
COAD	OS	Median	II,III,IV	0.477	0.791	.011	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

VCL–UCEC (OS)

Open the UCEC breakdown →