VCAN

Across TCGA pan-cancer cohorts, VCAN mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated VCAN data layer compared with 22 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher VCAN mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated VCAN expression acts as an unfavorable survival marker.

LSCC, LUAD, and CCRCC are the cancer types where VCAN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.541	0.857	<.001	60	view →
LUAD	OS	Tertile	All	0.787	0.946	.005	24	view →
CCRCC	OS	Median	IV	0.167	0.784	.038	8	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

VCAN–LSCC (DFS)

Open the LSCC breakdown →