VCAN-AS1

Across TCGA pan-cancer cohorts, VCAN-AS1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated VCAN-AS1 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher VCAN-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated VCAN-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and LGG show a favorable association.

BLCA, STAD, and ACC are the cancer types where VCAN-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.508	0.686	<.001	123	view →
STAD	DFS	Quartile	All	0.469	0.766	.001	89	view →
ACC	OS	Quartile	All	0.611	0.854	<.001	78	view →
UCS	DFS	Median	IV	0.952	0.367	.001	62	view →
UVM	OS	Tertile	All	0.220	0.917	<.001	54	view →
MESO	OS	Median	All	0.282	0.486	.002	53	view →
UCEC	OS	Tertile	All	0.892	0.940	<.001	48	view →
KIRC	OS	Median	All	0.571	0.735	<.001	45	view →
THCA	DFS	Quartile	IV	0.679	1.000	.004	38	view →
COAD	DFS	Tertile	III,IV	0.403	0.679	.019	31	view →
OV	DFS	Tertile	IV	0.296	0.523	.007	18	view →
HNSC	OS	Median	All	0.269	0.494	.005	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

VCAN-AS1–BLCA (OS)

Open the BLCA breakdown →