VCAM1

Across TCGA patient cohorts, VCAM1 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VCAM1-associated genes across cancer lineages are Notch1, MEK1, and PCNA. Each is linked with VCAM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both VCAM1-to-partner and partner-to-VCAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by VCAM1-low versus VCAM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VCAM1→partner) and Y-score (partner→VCAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.137	+1.775	.003	.007	3	3
UCEC	MEK1 →	+0.532	+2.643	<.001	<.001	3	2
UCEC	PCNA →	+0.199	+2.700	.005	.005	3	2
UCEC	Rictor_pT1135 →	-0.072	-2.459	.032	.018	3	2
UCEC	TIGAR →	+0.103	+1.178	.040	.034	3	2
UCEC	ATM →	-0.542	-4.000	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Notch1 by VCAM1 expression — UCEC

Explore this box plot interactively →