VCAM1

Across TCGA cell cohorts, VCAM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,257 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible VCAM1-associated GO terms across cancer lineages are Actin filament depolymerization, Alpha-beta T cell activation involved in immune response, and T cell differentiation involved in immune response. Each is linked with VCAM1 in more than 7 cancer types. Because this analysis shows association rather than direction, both VCAM1-to-partner and partner-to-VCAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament depolymerization grouped by VCAM1-low versus VCAM1-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VCAM1→partner) and Y-score (partner→VCAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Actin filament depolymerization →	+0.099	+0.043	.002	<.001	3	8
CNS	Alpha-beta T cell activation involved in immune response →	+0.108	+2.490	<.001	<.001	3	8
CNS	T cell differentiation involved in immune response →	+0.108	+2.490	<.001	<.001	3	8
BLOOD_Lymphoma	Negative regulation of non-canonical NF-kappaB signal transduction →	+0.121	+1.261	<.001	.003	3	8
SKIN	Regulation of extracellular matrix disassembly →	+0.112	+1.083	<.001	.004	3	7
SKIN	Negative regulation of myoblast fusion →	+0.128	+1.479	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,257 associations by consensus.

Actin filament depolymerization by VCAM1 expression — LARGE_INTESTINE

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