VBP1

Across TCGA pan-cancer cohorts, VBP1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated VBP1 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher VBP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated VBP1 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

COAD, CCRCC, and OV are the cancer types where VBP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	IV	0.493	0.944	.031	18	view →
CCRCC	DFS	Quartile	All	0.592	0.929	<.001	18	view →
OV	DFS	Tertile	All	0.591	0.884	.032	8	view →
PDAC	DFS	Median	II,III,IV	0.365	0.181	.034	4	view →
LUAD	DFS	Quartile	All	0.466	0.774	.011	3	view →
UCEC	DFS	Median	All	0.855	0.949	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

VBP1–COAD (DFS)

Open the COAD breakdown →