VAX2

Across TCGA patient cohorts, VAX2 mutation is significantly associated with the RNA expression of many other genes, with 255 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VAX2-associated genes across cancer lineages are RN7SL97P, MIR7702, and TMEM269. Each is linked with VAX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VAX2-to-partner and partner-to-VAX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL97P grouped by VAX2-low versus VAX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAX2→partner) and Y-score (partner→VAX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL97P →	+0.145	+2.754	<.001	.007	3	2
UCEC	MIR7702 →	+0.338	+4.890	<.001	.002	3	1
UCEC	TMEM269 →	+0.284	+3.354	<.001	.005	3	1
UCEC	OXSM →	+0.436	+3.227	.005	.009	3	1
UCEC	PKN3 →	+0.855	+3.332	.001	.005	3	1
UCEC	DOLPP1 →	+0.654	+3.332	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 255 associations by consensus.

RN7SL97P by VAX2 expression — UCEC

Explore this box plot interactively →