VAX2

Across TCGA patient cohorts, VAX2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VAX2-associated genes across cancer lineages are p62 Lck ligand, Di-Ras3, and Ku80. Each is linked with VAX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VAX2-to-partner and partner-to-VAX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by VAX2-low versus VAX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAX2→partner) and Y-score (partner→VAX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.589	+2.817	.001	.036	3	1
UCEC	Di-Ras3 →	-0.311	-3.000	<.001	.037	2	1
UCEC	Ku80 →	+0.415	+3.013	.002	.019	1	1
UCEC	MEK1 →	+0.477	+3.000	.024	.037	1	1
UCEC	Mre11 →	-0.104	-3.000	.035	.037	1	1
UCEC	Cyclin-B1 →	+0.794	+3.000	.014	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

p62 Lck ligand by VAX2 expression — UCEC

Explore this box plot interactively →