VAX2

Across TCGA cell cohorts, VAX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,174 significant associations in total. BONE shows the largest number of these associations.

The most reproducible VAX2-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Negative regulation of myoblast fusion, and PH reduction. Each is linked with VAX2 in more than 11 cancer types. Because this analysis shows association rather than direction, both VAX2-to-partner and partner-to-VAX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by VAX2-low versus VAX2-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VAX2→partner) and Y-score (partner→VAX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.133	+1.275	<.001	<.001	3	12
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.129	+1.230	.001	<.001	3	11
BREAST	PH reduction →	+0.995	+1.523	.001	<.001	3	11
OESOPHAGUS	Regulation of potassium ion transport →	-0.129	-1.049	<.001	<.001	3	11
LUNG_SCLC	Mitotic cytokinesis →	+0.109	+1.125	<.001	<.001	3	11
OESOPHAGUS	tRNA transcription →	+0.088	+0.919	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,174 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by VAX2 expression — OESOPHAGUS

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